Our Challenge
Conquering a Deadly Cancer
Patients with relapsed acute lymphoblastic leukemia face a devastating prognosis – and have few treatment options.
Our Breakthrough
Modifying Immune Cells to Fight Cancer
First cell therapy to be approved by the U.S. Food and Drug Administration
Our Solution
A Unique Approach
With philanthropic support, CHOP oncologist Stephan Grupp, MD, PhD, and colleagues find a way to modify patients’ own T cells so they can find and destroy cancer cells and persist in the body over long periods.
Our Impact
Many Lives Saved
Children from around the world, most of whom had no other treatment options left, have been treated with this unique immunotherapy at CHOP. After achieving remission, 70% of these children remained in remission at two years in our most recent study.
Stephan Grupp, MD, PhD
Director of the Cancer Immunotherapy Program and Director of Translational Research for the Center for Childhood Cancer Research
Shannon L. Maude, MD, PhD
Attending Physician, Immunotherapy, CAR T-cell Therapy
Help Us Find Solutions
We find real-world, scalable solutions to seemingly intractable problems. Led by the greatest minds in medicine, and with support from our generous donors, our world-renowned teams are taking on the toughest diseases the world has ever seen – and winning.
Epilepsy
Gene Therapy
